Functional gene expression differences between inbred alcohol-preferring and –non-preferring rats in five brain regions
نویسندگان
چکیده
منابع مشابه
Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats.
The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. Animals were killed 24 h after the last operant...
متن کاملFat-preferring rats consume more alcohol than carbohydrate-preferring rats.
Rats with a genetic preference for alcohol (ETOH) have been found to consume more dietary fat then ETOH nonpreferring rats. We therefore hypothesized that rats selected on the basis of fat and carbohydrate (CHO) preferences would differ in ETOH intake. Patterns of macronutrient self-selection were determined by allowing rats to select diets from separate sources of CHO, fat and protein. Subsequ...
متن کاملBehavioural features of alcohol-preferring rats: focus on inbred strains.
A recent study conducted a factor analysis on 18 behavioural measures obtained from four alcohol-preferring and five alcohol-non-preferring rat lines/strains. It was concluded that variables such as saccharin intake, ultrasonic vocalizations following an air puff, and defaecation in an open field were associated with voluntary and forced alcohol consumption. In contrast, measures such as time i...
متن کاملProteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats
Alcohol preference induced tolerance in humans and animals when their bodily functions adapt to compensate for the disruption caused by alcohol consumption. This was thought to be an important component of the genetic predisposition to alcoholism. To investigate the underlying mechanisms of hepatic metabolic tolerance during alcohol preference, the alcohol preferring and alcohol non-preferring ...
متن کاملTryptophan metabolism in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats.
Parameters of tryptophan (Trp) and related metabolism were compared in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats. Liver Trp pyrrolase activity was 38-58% higher in sP than in sNP rats, and this was associated with a greater expression of the enzyme mRNA as measured by multiprobe oligonucleotide solution hybridization. Moderately (about 10-19%), but significantly, low...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alcohol
سال: 2007
ISSN: 0741-8329
DOI: 10.1016/j.alcohol.2007.03.003